histone deacetylase (hdac) — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3206	NKL 22	Histone Deacetylase Inhibitor IV,PAOA	HDAC
	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.		HDAC
T2157	M344	MS 344,Histone Deacetylase Inhibitor III	HDAC
	M344 (Histone Deacetylase Inhibitor III) is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.		HDAC
T3193	Pimelic diphenylamide 106	Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8	HDAC
	Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs.		HDAC
T6055	Quisinostat	JNJ-26481585	Apoptosis , HDAC , Autophagy
	Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against...		Apoptosis , HDAC , Autophagy
T6481	Droxinostat	NS 41080	Apoptosis , HDAC
	Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.		Apoptosis , HDAC
T6865	Quisinostat dihydrochloride	Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis , HDAC , Autophagy
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g...		Apoptosis , HDAC , Autophagy
T8508	HDAC-IN-3	GSK3117391A	HDAC
	HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders.		HDAC
T3983	TMP195	TFMO 2,TMP 195	HDAC
	TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.		HDAC
T3358	ITSA-1	ITSA1	HDAC
	ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.		HDAC
T8517	Belinostat	PX105684,PXD101,PXD-101	HDAC , Autophagy
	Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.		HDAC , Autophagy
T21505	Suberoyl bis-hydroxamic acid	SBHA,Suberohydroxamic acid	Apoptosis , HDAC
	Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on ...		Apoptosis , HDAC
T73515	MC2590		Apoptosis , HDAC
	MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.		Apoptosis , HDAC
T17028	Tefinostat	CHR-2845	HDAC
	Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefino...		HDAC
T16962	SW-100		HDAC
	SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the...		HDAC
T1583	Vorinostat	MK0683,suberoylanilide hydroxamic acid,SAHA	Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy
	Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and i...		Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy
T2078	Fimepinostat	CUDC-907,PI3K/HDAC Inhibitor,CUDC 907	Apoptosis , PI3K , HDAC
	Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C...		Apoptosis , PI3K , HDAC
T77334	HDAC-IN-57		Apoptosis , HDAC
	HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 nM, and 107 nM, respectively. HDAC-IN-57 inhibits LSD1 with ...		Apoptosis , HDAC
T6678	Splitomicin	1-Naphthalenepropanoic Acid	Sirtuin , HDAC
	Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.		Sirtuin , HDAC
T14305	Apicidin	OSI 2040	Apoptosis , HDAC , Autophagy
	Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis ...		Apoptosis , HDAC , Autophagy
T1852	Rac-Belinostat	NSC726630,PXD101,PX-105684	HDAC
	Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptos...		HDAC